De-Extinction? Surely You’re Joking

70 points by 2mol 2 years ago | 89 comments
  • leidenfrost 2 years ago
    I don't see the point of de-extinction other than naturist nostalgia.

    The problem around de-extinction is that you can't just shoehorn a new species into a habitat that already filled the void left by a past extinction.

    If some marsupial in Australia got extinct because it was replaced by feral cats, then that habitat won't welcome that marsupial anymore. And there's nothing we can do about it. Even if we somehow people organize themselves to hunt all the feral cats to extinction, it will either be replaced by new post-domestic cats or either some other, equally capable and already existing predator.

    The habitat wasn't destroyed nor hurt in anyway. It just changed. It changed the same way it changed when all non-avian dinosaurs got extinct and then replaced with mammals and birds that filled the void left by them.

    • DennisP 2 years ago
      Sometimes the holes don't get filled. Mammoths in northern steppes are one example, and getting them back would actually be pretty helpful.

      https://www.smithsonianmag.com/science-nature/can-bringing-b...

      • patall 2 years ago
        Another great example are Avocados, Papayas, Zapotes, Honey-locusts and other American large-seeded fruit that have no known seed dispersal mechanism anymore. All the big mammals that like giant sloth (and again, the mammoth) that would eat the fruit and later poop the seed somewhere else are gone and it's kind of a surprise that so many of those survived the last 13,000 years (and nobody knows what we may have lost during that time).
      • patall 2 years ago
        I fully disagree. There are so many examples of animals that once de-facto disappeared (like huge sea-lion colonies, same for turtles, reintroduced american and/or european bison, black footed ferret, arabian oryx, hermit ibis, wolves, ...) and then came back, to restore their original biological role. You cannot release a mammoth into central park and hope that it just works. But nobody is trying to do that.
        • Ensorceled 2 years ago
          > The habitat wasn't destroyed nor hurt in anyway. It just changed.

          That's an interesting way to describe the massive effect humans are having on pretty much every habitat on the planet ... "It just changed."

          • leidenfrost 2 years ago
            Because in the end, that's really it. Even if it's due to human intervention and even if that makes us feel sad.

            At some point, a new habitat will reach a new balance with our introduced species and there's no going back.

            And yes, there may be less diversity in species all over the world (for the time being) thanks to that. But once the new species learn to reproduce and survive in a new place, then that is the "new" state of the habitat.

            I agree we should strive to not fuck up our place on the planet. But habitats will change whether we like it or not.

            Maybe in a million years feral cats in Australia will differentiate themselves with the ones in Europe.

            • joshuahedlund 2 years ago
              > At some point, a new habitat will reach a new balance with our introduced species and there's no going back.

              > And yes, there may be less diversity in species all over the world (for the time being) thanks to that. But once the new species learn to reproduce and survive in a new place, then that is the "new" state of the habitat.

              Yeah but won't that be just as true of a re-introduced de-extincted species? Mammoths / mammoth-ish elephants might change the new equilibrium in Siberia just like it changed when they were extincted in the first place... maybe the change could even be for the good. Why is the latter just accepted but the former is not?

              There's this weird status quo bias that seems to say "ecosystems re-adjusting if humans deliberately re-introduce a species is artificial and must be bad" while also saying "ecosystems re-adjusting when humans literally do everything else that humans do is somehow natural or fated"

              • anonymous_sorry 2 years ago
                Human societies are coming to value and protect biodiversity. Extending your argument this is just another change in the habitat, one for which native species may be better adapted. Judging by the rules on what you're allowed to bring in to the country, Australia now appears to take invasive species very seriously.
                • ElevenLathe 2 years ago
                  I can imagine de-extinction and other genetic engineering techniques being useful to increase the amount of diversity in many habitats, which will theoretically give them a better chance of weathering huge environmental changes (as natural selection has a broader base of genes to work against). Since we need the biosphere to continue existing in a pretty narrow range of configurations in order to keep us alive (for example, we probably don't have the technology yet to sustain our civilization in the face of the whole planet becoming a desert, or not providing enough oxygen to breathe without artificial assistance), this might be a useful technique.
                • some_random 2 years ago
                  You can say things in a value neutral way and have them still be true.
                  • Ensorceled 2 years ago
                    > > The habitat wasn't destroyed nor hurt in anyway.

                    > You can say things in a value neutral way and have them still be true.

                    How is that statement "value neutral"?

                  • mrits 2 years ago
                    I think my dog prefers her swimming pool and heart worm medication so she can live more than a few years. Humans have a negative effect on some ecosystems but it seems inevitable that viruses,fungi,etc will eventually take over without our intervention.
                    • kybernetyk 2 years ago
                      Which isn't wrong. As humans are the product of evolution, humans changing habitats is just natural change.
                      • msm_ 2 years ago
                        This is technically correct, but I think this misses the point. Unhabitable future Earth with molten icebergs and polluted gray sky may, technically, be a "natural change" and a consequence of "natural" human actions.

                        But we, humans, want to avoid this future. The same goes for causing extinction of most wild animal species.

                        Edit: to expand on GP's point: imagine your house burned down, and somebody said "> Your property wasn't destroyed nor hurt in anyway. It just changed". Yeah, all the atoms are still there, but it changed in a way we find undesirable.

                        • Ensorceled 2 years ago
                          You can defend all sorts of things with that reasoning ... "humans are tribal by nature, so war is just natural"
                      • dividedbyzero 2 years ago
                        Bringing back beaver and wolves to areas where they've been wiped out is functionally the same and shows that often such niches don't get filled all that fast. The replacement for wolves has been hunters, beavers had no replacement. Usually when either gets reintroduced, the local ecosystem functions quite a bit better, there has been quite a bit of backlash by hunters because it turns out wolves do a substantial part of their work and there is less need to control deer populations. Might not work in all cases, but even if partial restoration is an option, having that genome around is a good thing in itself, as life thrives off diversity. Reducing genetic diversity hampers an ecosystem's ability to adapt to change. We have a lot of ecosystems that have been decimated to the point of being close to unviable, and we're losing keystone species all the time. Fixing what drove them over the cliff (hard if it's feral cats, easier if it's a specific pesticide, disease, hunting, or habitat fragmentation) and subsequent reintroduction may well prove a pretty important strategy to keep the world a place that humans can thrive in, especially given the predicted decrease in world population by the end of the century which may result in renaturation of swathes of land.
                        • mo_42 2 years ago
                          I see two points: 1. scientific curiosity, and 2. people might enjoy seeing these animals.

                          Also, humans are terraforming this planet anyway so I don’t see a reason not to do it in a way to make room for previously extinct species.

                          Some other discussion could be if those animals would be happy living. Maybe we will have to ask whether we de-extinct Homo Erectus. Apparently, we're not even asking this for animals we eat…

                          • GalenErso 2 years ago
                            I see another point which ties with your second: 3. Money

                            "And we can charge anything we want, 2,000 a day, 10,000 a day, and people will pay it. And then there's the merchandise..."

                            • kurthr 2 years ago
                              That's how it really works. They'll be show animals.

                              "Think how many ideas were lost, and eventually forgotten, when those animals went extinct... like what did they taste like?"

                            • klyrs 2 years ago
                              3. The dodo went extinct because, by all accounts, they were delicious
                              • timeon 2 years ago
                                > to make room for previously extinct species

                                There is barely room for contemporary species.

                                • ethanbond 2 years ago
                                  After accounting for the enormous swaths of monoculture land required to grow plants to feed animals to slaughter for human consumption, sure.

                                  If we can figure out how to reduce that though, there’s plenty of land.

                              • antichronology 2 years ago
                                I think the apt comparison here is landing on the moon. Although overtly it carries little value, the technologies developed along the way are very valuable.

                                As the article mentions improved fertilization, more accurate genome editing, and advances in in-vitro gastrulation are the real prize.

                                To me there is also something profoundly sad about the loss of molecular information with each extinct species. Having a simple hope, perhaps naive, to reverse this process is comforting.

                                • Bronze_Colossus 2 years ago
                                  In regarding the Mammoth there is some who claims that bringing the Mammoth back would help recreate the northern subarctic steppe grassland ecosystem that flourished in Siberia during the last glacial period. This would increase the animal density in Siberia and so on.
                                  • mc32 2 years ago
                                    It's unlikely these resurrected species will inhabit their ancestral habitats but rather, like Jurassic Park, satisfy human curiosity and entertainment for nature itself does not care one way or the other.

                                    Just think, eventually and extinct species zoo garden, not unlike JP, except more tame species... maybe. It would be a destination attraction for sure.

                                    • timeon 2 years ago
                                      That sounds bit perverse.
                                    • ignoramous 2 years ago
                                      The habitat may also come to be dominated by a bully species due to human intervention (think: plastic pollution causing Turtle deaths and thus rise in Jellyfish population) which may result in extinctions of a variety of other species.
                                      • andrewclunn 2 years ago
                                        Rich people spend money on a fancy boat, nobody gives a damn. Rich people spend their money on some charity or philanthropic endeavor, "Shame! You should spend that money on THIS charity instead!"
                                        • LatteLazy 2 years ago
                                          I don't think that's true. Leaving aside that feral cats will just re-extinct the species, whatever other species has filled it's niches is very unlikely to be as good as that as the original.
                                          • BiteCode_dev 2 years ago
                                            If someone went to set your house on fire, empty your bank account and kill your family, I'm pretty sure "your life wasn't destroyed nor hurt in anyway. It just changed" would not be well accepted by you.
                                            • carapace 2 years ago
                                              Are you an ecologist?
                                            • rcMgD2BwE72F 2 years ago
                                              >Critics say that Colossal’s money would be better spent in protecting existing species, rather than de-extinct animals that have been dead for thousands of years. Maybe that’s true, but it’s extremely unlikely that this $150M would have gone to conservation otherwise! If rich people want to spend their money on de-extinction, and bolster reproductive technologies in the meantime, then we say “let ‘em.”

                                              There's a French idiom for that, "pompiers pyromanes", which means arsonist firemen. Seems appropriate.

                                              • IntrepidWorm 2 years ago
                                                In 1800's United States, fire departments in many large cities (Chicago and New York, to name two) were private for-profit industries. If a homeowner did not pay what was effectively protection money, the fire department would refuse to extinguish your property if it caught fire, and would sit around as the dwelling burned, in some cases with people still inside.

                                                Fascinating idiom, thanks!

                                              • BurningFrog 2 years ago
                                                Protecting existing species is a different goal though.

                                                It's always true that if you have different goals you'd spend resources differently.

                                                • fastball 2 years ago
                                                  That doesn't really sound like the same thing?
                                                • vinaypai 2 years ago
                                                  This reads like a typical hatchet job with the usual fallacy of extrapolating from "didn't immediately succeed" to "is impossible".
                                                  • mkoubaa 2 years ago
                                                    It's even worse. The claim sounds like: "Billion dollar company needs to invent new things to succeed, surely it is doomed to fail."
                                                  • remote_phone 2 years ago
                                                    This author spends a lot of time pooh poohing the idea without considering the fact that research could result in techniques that don’t exist right now. That’s the whole point in science and investing in research!

                                                    How about instead of bemoaning how “money could be better spent on conservation”, the author could pursue that route (they won’t) and let people who are interested in research do what they want to do?

                                                    • ramraj07 2 years ago
                                                      I don’t understand why people are obsessed with extinction as some great evil - it’s as evil as the concept of death itself; killing something is evil (or is it not? Outside humans even this isn’t considered unnatural), but something dying naturally is not.

                                                      Clearly many animals have gone extinct because of humans (many memorable ones before humanity developed a sufficiently profound collective consciousness that could ponder about this), but I don’t see how there’s any moral, ethical or natural urge to repent and offer reparations for this. Species die, that’s the natural order of things for species in general and if this round of mass extinction is humanity induced then we should focus on reducing its scale instead of trying to go undo it as if that absolves us of anything.

                                                      This says nothing about the scientific ability to do this, anyway, which as this article points is mostly BS. My general experience is if you try to do something that doesn’t make full logical economical and moral sense, you end up with this charlatan group. Crypto is another example of the same.

                                                      • lovich 2 years ago
                                                        > Species die, that’s the natural order of things for species in general…

                                                        When we say “natural” we’re already being anthropocentric by dividing reality between things that happen because of humans and everything else. You can’t hand wave away what’s occurred because of our behavior by point to the “natural order of things” when it explicitly isn’t.

                                                        As to why people are obsessed. It’s just a value judgement? You might as well asked why certain groups are obsessed with getting in orderly queues and other groups deal with lines as competition to get to the front.

                                                        If you value not killing off other species then undoing an extinction would most definitely absolve you of that sin. I can see how if you personally don’t care about extinctions you wouldn’t care about undoing them, but you need to be able to put yourself in other people’s shoes to be able to understand the answer to your question.

                                                        • mdavidn 2 years ago
                                                          > I don’t understand why people are obsessed with extinction as some great evil

                                                          It's because we care about our children and their children. Each extinction eliminates a species that our ancestors lived among or depended upon. Eventually, an extinction may fundamentally break a food chain that keeps our descendants alive.

                                                          • ramraj07 2 years ago
                                                            Each extinction eliminates a species yes, but long term it opens up a niche for a new species to evolve into. As a biologist I don’t see any fundamental problem with this ebb and flow. We as a species haven’t exactly put down our foot on actual individual suffering so it just seems hypocritical to ascertain extra value to extinction, which outside of some vague concepts we have made up have no real ecological relevance anyway.
                                                          • sklivvz1971 2 years ago
                                                            Maybe this can help: https://en.wikipedia.org/wiki/Biodiversity_loss

                                                            In very short terms: lack of biodiversity makes the ecosystem brittle and susceptible to collapse with changing selective pressure.

                                                            • cmh89 2 years ago
                                                              I personally don't want to live in a bland, dead world.

                                                              To me its like climate change. The climate change, just like species go extinct. But humans are exasperating both processes in a ways that will ultimately make living on earth worse for future generations.

                                                              • BurningFrog 2 years ago
                                                                Species going extinct doesn't make the world deader.

                                                                "Bland" is a better argument. If one bird species spreads across the world and outcompetes 10 regional species, there will be just as many birds as before. There will be less regional variation though.

                                                                • cmh89 2 years ago
                                                                  >Species going extinct doesn't make the world deader.

                                                                  It depends on why the went extinct. If they went extinct because humans destroyed the habitat, rather than being out competed, then it's unlikely as much life or any life can just move in.

                                                                  See the coral reefs or Klamath river

                                                                • AlexandrB 2 years ago
                                                                  It won't be a dead world - but I sure hope everyone likes rats, cockroaches, and jellyfish - because these are the species that seem to be well adapted to living in environments where other animals have been driven out.
                                                                  • a13o 2 years ago
                                                                    Don't forget humans in that list
                                                                    • ozim 2 years ago
                                                                      Well there will be crabs as well because of carcinisation
                                                                  • Ericson2314 2 years ago
                                                                    The article also illustrates the problem of the gap between research and development.

                                                                    We have a bunch of technologies mentioned that are perhaps out of the pure basic research stage, but need to be developed a bunch. Developing those can be done independently and in parallel, but is that happening? Trying to put them all together probably is premature as the article suggests, and yet this is the easiest way to raise money because it is catchy.

                                                                    • pessimizer 2 years ago
                                                                      Extinction is the complete destruction of something that took millions of years to make. As much as it seems like people create the world they live in, they don't. We ingeniously assemble the world we live in out of the great diversity of material around us. It's better that we have wheat now than the world in which we didn't. It's better that we have tomatoes, corn, chickens, etc.. Without them, our lives would likely be more difficult and less pleasurable. Tomorrow's tomatoes and chickens may have been killed today partially out of greed, but mostly out of carelessness and lack of understanding.

                                                                      > I don’t understand why people are obsessed with extinction as some great evil - it’s as evil as the concept of death itself;

                                                                      If you characterize worrying about extinction as being obsessed, would you characterize worrying about death to be an obsession we should rid ourselves of? Why should I worry if people are dying, people always die, doesn't matter?

                                                                    • mkoubaa 2 years ago
                                                                      It isn't what the author intended but I come away from reading this more confident that mammoth de-extinction will happen.
                                                                      • Robotbeat 2 years ago
                                                                        Maybe the juicy headline was written by the editor?
                                                                      • DarkContinent 2 years ago
                                                                        Is there someone on HN who can speak to how fast gene editing technology is improving? I was a bit skeptical of the author's claim that construction of a mammoth genome would require 5000 years, but I couldn't find any information in a cursory search on what the technology improvement speed is.
                                                                        • Robotbeat 2 years ago
                                                                          Well it used to take ~infinity years as the technique didn’t exist to do it at all.

                                                                          Claims like “it’ll take 5000 years” are always funny because they’re so incredibly status quo biased, without the least bit of self consciousness of how remarkable the progress has been in the last 50 years on things like this.

                                                                          Humans overestimate progress in the near term and underestimate progress in the long term.

                                                                        • denton-scratch 2 years ago
                                                                          > after scientists cloned an animal and watched it die, moments later, from a lung defect

                                                                          Moments after they cloned it? The immediate result of cloning is a single cell, not something with a lung. So that single cell grew into an organism with lungs, in moments?

                                                                          I stopped reading a few paragraphs after that.

                                                                          • M95D 2 years ago
                                                                            I think the author missed one of the most important points: genetic variability to obtain the minimum viable population.[1]

                                                                            Let's say they make a perfect clone of an extinct animal. It can't reproduce by itself. It needs a mate. Let's say they clone a second animal of the other gender. Let's say they reproduce (low chance of that, but let's say they do). All their descendants need mates too, other than their siblings, otherwise it leeds to inbreeding.[2]

                                                                            They need dozens if not hundreds of different individuals to make a viable population that doesn't go extinct again.

                                                                            [1] https://en.wikipedia.org/wiki/Minimum_viable_population [2] https://en.wikipedia.org/wiki/Inbreeding_depression

                                                                            • Nasrudith 2 years ago
                                                                              Technically that could be overcome if you don't care about individual specimen welfare and mutate until you get viable specimens. It won't be quite the same but it would restore a viable species.
                                                                              • M95D 2 years ago
                                                                                > mutate until you get viable specimens

                                                                                Mutations are very rarely viable. In fact, the original cloned animal mutations must be eliminated in order to have viable future generation. The only thing that (may) benefit from mutations is the imune system. See the problem with cheetah's lack of genetic variability: https://en.wikipedia.org/wiki/Cheetah#Genetics

                                                                            • xeeeeeeeeeeenu 2 years ago
                                                                              >Captain Cook’s Bean Snail [...] Today, they live only in zoos.

                                                                              Sadly, the last member of that particular species died in 2016, in Edinburgh Zoo[1]. However, they had some success with other Partula snails[2].

                                                                              [1] - https://islandbiodiversity.com/faba.htm

                                                                              [2] - https://www.rzss.org.uk/conservation/our-projects/project-se...

                                                                              • TheCaptain4815 2 years ago
                                                                                I've always wondered what the end goal was for animal preservation. Halting evolution and keeping the same ecosystem around forever?
                                                                                • sklivvz1971 2 years ago
                                                                                  > Critics say that Colossal’s money would be better spent in protecting existing species

                                                                                  Ah, ye old whataboutism canard... it seems to be forgetting that this technology would have an immense value by itself!

                                                                                  > True de-extinction is nowhere near possible.

                                                                                  I'm not sure I can parse the convoluted English here. Are we saying it's impossible? I see no evidence in the article that it is correct. Are we saying it's really hard? Sure, but no one claimed otherwise.

                                                                                  I am not the kind of person that tends to have starry-eyed faith into any appealing idea, and perhaps it is truly hard to "resurrect" a dead species. However it seems to me that it's obviously doable at some level: Craig Venter has created a synthetic bacterium so I don't see why a particularly simple life form can't be "de-extincted".

                                                                                  I realize though that multicellular organism are much harder and quite far away from our current capabilities, but impossible? I don't see why.

                                                                                  • StrictDabbler 2 years ago
                                                                                    Yes, and the technologies involved in attempting de-extinction are also useful in preserving existing species.

                                                                                    A species that has dwindled to about ten living individuals has a shallow gene pool.

                                                                                    Bringing in genes from recently deceased or preserved specimens could help deepen that pool.

                                                                                    It has happened that only one female of a species was known to be alive. The ability to put together a viable egg for her to bring to term would be the difference between extinction and survival.

                                                                                    We're also awfully mammal-centric. Frogs have already been de-extincted. The gastric-brooding frog was resurrected in 2013.

                                                                                    Compared to mammals it is relatively easy to transfer DNA around between the eggs of related oviparous species and there's no real reason we can't make a large-scale DNA bank for them, protecting the endangered birds, fish, reptiles and amphibians of the world.

                                                                                    These technologies are all part of one tech tree.

                                                                                  • danrocks 2 years ago
                                                                                    I’m not, and don’t call me Shirley.
                                                                                  • Ruq 2 years ago
                                                                                    Jurassic Park anyone?
                                                                                    • v3ss0n 2 years ago
                                                                                      Therenos 2.0?
                                                                                      • jonnylynchy 2 years ago
                                                                                        I AM serious. And don't call me Shirley.
                                                                                      • sebastianconcpt 2 years ago
                                                                                        Don't we had a lot of movies explaining how bad this could go? Don't we had enough self inflicted catastrophes to keep us entertained that we need another disruptive one?
                                                                                        • tokai 2 years ago
                                                                                          Not a single one of those movies are an actual argument against a real de-extinction project.
                                                                                          • shukantpal 2 years ago
                                                                                            Yes, because the parent comment's point was they are an argument _against_ not _for_ de-extinction
                                                                                            • tokai 2 years ago
                                                                                              Obviously. Edited the missing words in my comment.
                                                                                            • sebastianconcpt 2 years ago
                                                                                              Well, I find the arrogance in trying to undo Natural Selection quite cute. She'll win. Big time.
                                                                                              • Robotbeat 2 years ago
                                                                                                Pretty sure humans caused the extinction of many of the target de-extinction animals. We became insanely good hunters, and killed off just a massive amount of megafauna like mammoths, and then we proceeded to do it to a ton of other species.

                                                                                                I am not so fatalistic about humanity’s environmental impact to just chalk it up to “well, see, mammoths shouldn’t have been so easy for humans to kill and so tasty…” or the same thing applied to any of the more recent species due to habitat loss, etc. (“sorry you can’t thrive in suburbs or clear cut fields, evolution is a b*tch, ain’t she?”)

                                                                                                Humanity’s capacity for higher level reflection is ALSO “natural” in the same sense, so all of these de-extinction projects are equally “natural.”

                                                                                                • autophagian 2 years ago
                                                                                                  Where's the line when it constitutes 'undoing natural selection'? Resurrecting extinct animals? Conservation efforts? Taking antibiotics?
                                                                                              • vinaypai 2 years ago
                                                                                                You mean Jurassic Park, that famous parable of the need for better fences?
                                                                                                • Nasrudith 2 years ago
                                                                                                  People seem to be forgetting the meaning of "fiction" recently. Citing Jurassic Park makes about as much sense as citing cyberpunk's loss of humanity trope from cybernetics as the reason why amputees should be denied functional prosthetics.
                                                                                                • mrozbarry 2 years ago
                                                                                                  I think any attempt at "de-extinction" is quite literally a statement of disbelief of evolution. A core tenant (at least from my perspective) of evolution is survival of the fittest. I agree with all the other comments mentioning that the voids that extinct animals left have been filled and their ecosystems have changed, but that is different from their ecosystems being destroyed. Accept change, and move on. Also, humanity has a track record of trying to play god and that not going too well.
                                                                                                  • pessimizer 2 years ago
                                                                                                    Evolution isn't a doctrine that you're supposed to follow, that's social Darwinism.
                                                                                                    • drc500free 2 years ago
                                                                                                      Any attempt at "building anything at all" is quite literally a statement of disbelief in entropy.